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KMID : 0644120180310040089
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Journal of Oriental Gynecology
2018 Volume.31 No. 4 p.89 ~ p.109
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Clinical Research of the Effect of Traditional Herbal Medicine with In Vitro Fertilization and Embryo Transfer in Pubmed
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Lee Mi-Joo
Son Sung-Se
Park Seung-Hyeok
Park Kyoung-Sun
Hwang Deok-Sang
Lee Jin-Moo
Jang Jun-Bock
Lee Chang-Hoon
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Abstract
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Objectives: The purpose of this systematic review is to assess the effects of herbal medicine with in vitro fertilization-embryo transfer (IVF-ET) based on the current evidence.
Methods: Eligible randomized controlled trials (RCT) searched from Pubmed which compared a combination of herbal medicine and IVF with IVF alone were included.
Results: Sixteen trials, in which 2025 women involved, were included in this review. The review results showed that the effect of traditional herbal medicine can improve the clinical pregnancy rate (herbal medicine intervention: 30.36~63.64%, Control: 9.38~47.5%) and rate of high quality oocytes and embryos. The mechanism may be through regulating follicular fluid to improve microenvironment for oocytes which would lead to a successful embryo implantation.
Conclusions: This analysis showed that combination of IVF and traditional herbal medicine used in the included trials improve clinical pregnancy rate and IVF success. During in vitro fertilization, TCM can regulate the microenvironment in the follicular fluid to mature the oocyte, improve the quality of the embryo, and help the development and implantation of the embryo. Further large randomized placebo controlled trials are needed to confirm the effectiveness of traditional herbal medicine with concurrent IVF.
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KEYWORD
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In Vitro Fertilization, Embryo Transfer, Herbal Medicine, Pregnancy Rate
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